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Scientist - AAV Analytical Development Molecular Assays

  • Location
  • Job type Permanent
  • Reference BBBH120053

Scientist - AAV Analytical Development Molecular Assays

We are a fully integrated AAV engineering and gene therapy company poised to create
the next generation of innovative genetic therapies with life-changing potential for
patients with grievous unmet medical needs.

We leverage our proprietary high-throughput, data science driven AAV engineering
platform to create viral vectors with cell-type and tissue level specificity, overcoming
many of the biological limitations of early gene therapy efforts. Combined with our inhouse
preclinical and manufacturing expertise, we are positioned to create the next
generation of AAV delivered gene therapies, dramatically changing the lives of patients.

We are founded on the idea that diverse backgrounds and skill sets combine to create
an environment that stimulates innovation and creativity, enabling us to grow into a
leader in the AAV gene therapy space. Our leadership team is comprised of the scientific
founders that developed the underlying intellectual property, and experienced industry
veterans with a track record for brining transformative drugs to market. Together with
our partners, we will combine next generation engineered capsids with cutting edge
gene editing and delivery modalities to bring novel medicines to patients that need
them. Our research and development labs, offices, and manufacturing space are located
in Newbury Park, near the Amgen campus.

Scientist- AAV Analytical Development- Molecular Assays

We are looking for a motivated scientist to join the AAV analytical development team.
The goal of this position is to lead the development of molecular assays for the testing
of AAV vectors. Under the guidance of senior leadership, you will design and execute
experiments focusing on the development of assays for the detection and
characterization of vector genomes and process impurities. A successful candidate will
have strong technical and organizational skills and work seamlessly with a team.
Laboratory activities will constitute approximately 75% of the time.

Major Responsibilities

  • Lead the analytical development team in designing molecular based assays for quantifying and characterizing viral DNA and process related impurities
  • Optimize analytical methods to increase accuracy and throughput
  • Test vectors from various stages of development and production to support process development and research activities
  • Work with external partners to evaluate new technologies
  • Maintain accurate and detailed laboratory notes
  • Contribute to the maintenance and upkeep of lab operations
  • Author technical materials, procedures, protocols, and reports
  • Plan, schedule, and execute on experimental designs in collaboration with senior leadership
  • Conduct troubleshooting experiments
  • Perform additional tasks as assigned

Essential Requirements:

  • B.S. (minimum of 5-8 years), M.S. (minimum of 3-5 years), or PhD (minimum 0-2 years) in life sciences with relevant experience in a biotechnology, pharmaceutical, or academic setting.
  • Detailed understanding of standard molecular biology techniques (qPCR or ddPCR, gel electrophoresis, Southern blotting)
  • Knowledge of assay design for both quantification and limit of detection methods
  • Experience developing and optimizing protocols or standard operating procedures.
  • Experience with Sanger or next-generation sequencing preferred
  • Excellent organizational and collaborative skills, with the ability to design and troubleshoot experiments with minimal supervision or as part of a group.
  • Prior experience working with gene therapy vectors strongly preferred
  • Must be eligible to work in the U.S.

Compensation and Benefits:

The well-being of our employees and their families is of the highest importance. As such, we
offer a competitive salary and exceptional benefits, including generous stock options,
medical, dental, vision, disability, life insurance, and significant PTO.

Additionally, we offer:

  • Relocation compensation
  • Fully stocked kitchen
  • Social lunches, happy hours, and other events on a regular basis

We are an equal opportunity employer. All applicants will be considered for employment without
attention to age, race, color, religion, sexual orientation, gender identity, national origin, veteran or
disability status, or any classification protected by federal, state, or local laws